PATHOPHYSIOLOGY OF FACTORS AFFECTING FERTILITY | FERTILITY AND INFERTILTY

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Ovarian and Ovulation Factors
     Diagnostics studies performed to determine if ovulation is regular and whether the progestational endometrium is adequate for implantation may include a serum progesterone level and an ovulation index. The ovulation index involves a urine- stick tests to determine whether the surge in LH that precedes follicular rupture occurred. Ovulatory dysfunction is complex, but many women with ovulation disorders have prolycystic ovary syndrome, and may be treated with clomiphene to induce ovulation or insulin sensitizing agents. Once insulin levels are normalized, ovulation often occurs. Some women have high prolacting levels, which inhibit ovulation, and they are treated with dopaminergic drugs after a pituitary adenoma is ruled out by MRI. If a woman has premature ovarian failure, oocyte donation may be considered.
Tubal and Uterine Factors
     HSG is used to rule out uterine or tubal abnormalities. A contrast substance introduced into uterus via the cervix gives an identity of the shape of the uterine cavity and the patency of the tubes. This process sometimes removes mucus or tissue that is lodged in the tubes. Laparoscopy permits direct visualization of the tubes and other pelvic structures and can assist in identifying conditions that may interfere with fertility (e.g endometriosis).
     Fibroids, polyps, and congenital malformations are possible causative factors affecting the uterus. Their presence may be determined by pelvic examination, hysteroscopy, saline sonogram ( a variation of a sonogram), and HSG. Endometriosis, even if mild, is associated with reduced fertility.
MALE FACTORS
     An analysis of semen provides information about the number of percentage of moving forms, sperm (density),  and morphology (shape and form) quality of forward movement (forward progression),. From 2 to 6 mL of watery alkaline semen is normal. A normal count has 60 to 100 million sperm/mL. However, the incidence of impregnation is lessened only when the count decreases to less than 20 million sperm/mL.

     Men may also be affected by varicoceles, which decrease semen quality by increasing testicular temperature and varicose veins around the testicle,. Retrograde ejaculation or ejaculation into the bladder is assessed by urinalysis after ejaculation. In  male partners testing of blood may include the measuring of testosterone; LH and FSH ( which are involved in maintaining testicular function); and prolactin levels.

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